Al Mayadeen App enables you to watch the channel’s live streaming 24-hour a day. It delivers the regions’ breaking news, articles, videos and even Al Mayadeen Programs right to your mobile. This app keeps you informed with all breaking news happening around the globe. In 2002 the TV channel was shut down by the lebanese governement. Stay updated and get the latest news on the go with Al Mayadeen News app. Mtv is a news TV channel covering regional and world news. 73K views, 3. The channel aims at reducing the influence of Al Jazeera and Al Arabiya. Don’t miss out on the news and stories that are shaping our world. Lebanese Television company to establish a presence on the World Wide Web in March 1996. With live streaming and in-depth reporting, you’ll be able to stay informed about the events and stories that matter most to you, no matter where you are in the world. It is a Lebanese owned and operated company that was founded in 1993. Mission is to highlight the importance of Palestine and Jerusalem for the Arab and Islamic nation and its centrality.įuture TV News is a general TV channel with news and informative programming. The chann is dealing with the Palestinian issue and is licensed in London and has offices in Gaza Strip, the West Bank, Beirut and Damascus. Dell photo aio printer 926 download Convert csv to vcard online How to make mac n cheese more creamy Al mayadeen livestation I am one of the few honest. It covers the news with daily news reports and many distinctĪl Quds al Arabi News TV channel. The channel aims at reducing the influence of the Al Jazeera and Al Arabiya. TV channel is: A Flame that will not be Extinguished.Īl mayadeen was founded in 2012. Al-Mayadeen Media Network is an independent Arab satellite news channel, launched on June 11, 2012, and based in Beirut, Lebanon. About Press Copyright Contact us Creators Advertise Developers Terms Privacy Policy & Safety How YouTube works Test new features NFL Sunday Ticket Press Copyright. It has an offering high production news, commentary, and entertainment. The recent years the channel is under attack by threats and intimidation attempts.Īl-Manar is a Lebanese satellite television station based in Beirut. Al Jadeed it not affiliated with a political party. The service was originally based on peer-to-peer technology acquired from Microsoft Research. and is now an independent company called Livestation Ltd. 2 It was originally developed by Skinkers Ltd. The channel started broadcasting in 2001. Livestation was a platform for distributing live television and radio broadcasts over a data network. Platform to promote the values of tolerance, democracy and respect for human rights and freedoms.Īl Jadeed is a privately owned 24-hour pan-Arab TV station, based in Beirut. It pretents to be the voice of the Arabs in the Diaspora and a bridge of communication between the Arabs and the rest of the peoples and cultures, and a
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Follow them on Facebook for more details. After all, the best things in life are right in your own backyard.Īccording to John Antilla, the General Manager, ‘We’re very excited to be emerging from the pandemic with a beautiful new retail location right in the heart of the vibrant, fast-growing city of Woodinville’. Above ground pools are available in round or oval and come in many. The attractive and durable construction of above ground pools will ensure you and your family’s safety and enjoyment of a swimming pool without the heavy expense of construction. The team not only guarantees long-lasting products but also provides proper service and maintenance to extend the life of the products for years to come. Spend more quality time with your friends and family at an affordable cost. This new location also offers an impressive range of pool and spa water care products, pool heaters and equipment, filter cartridges, automatic cleaners, BBQ Cleaning, Electrical services, Spa and Pool Maintenance, pool construction free water testing, and an inspiring online shopping experience.Ĭommitted to delivering a high degree of customer satisfaction, Aqua Quip is driven by a team of trained and reliable professionals who are licensed, certified, and factory-trained to offer the best leisure experience to customers. The new store features a wide range of industry-leading brands including Hydropool swim spas, Jacuzzi hot tubs, Finnleo personal saunas, Regency gas, pellet, and wood-burning fireplaces and inserts, pools both inground and above ground, and a complete selection of BBQ’s from well-known brands Weber, Saber, Big Green Egg, and Green Mountain Grills. The company is pleased to announce the opening of their newest retail location in Woodinville, Washington located in the Downtown Woodinville Shopping Center at 13970 NE 178th Pl, Woodinville, WA 98072. Woodinville, Washington ( ) - Serving the greater Seattle Area since 1959, Aqua Quip provides quality products and services for creating lifelong memories in the backyard oasis of your dreams. As the first ionisation energy decreases as you move down the group, less energy is required to move the electrons, therefore the elements become more reactive. Reactions of Group 2 elements consist of the elements losing electrons to form ions with a +2 charge. As you move down Group 2, the reactivity of the elements increases.When they react with water, they form the hydroxide and hydrogen gas. The attraction between the outermost electrons and the nucleus decreases, therefore less energy is required to remove them. They exist almost exclusively in the +2 oxidation state. The shielding effect on the outermost electrons also increases due to the presence of more inner electron shells containing electrons. More electron shells are added as you move down Group 2 which means the atomic radius increases and therefore the outermost shell becomes further and further away from the positive nucleus. As you move down Group 2, the first ionisation energy of the elements decreases.Between beryllium and radium, there is a change in the melting point trend at magnesium as it has a different crystalline structure.įirst Ionisation Energy Trend Down Group 2 The arrangement of the Group 2 ions in the metal affects the melting point.Less energy is needed to break the metallic bonds as the delocalised electrons are further away from the positive nuclei because of an increased ionic radius, therefore there is a decreased attraction between them. The charge of +2 of of the positive ions does not change either. As you move down the group, the radius of the metal ions increases but the number of delocalised electrons stays the same per atom. Group 2 elements generally have metallic bonding as they are metallic structures. As you move down Group 2, the melting points of the elements decreases.The atomic radius of Group 2 elements decreases because more and more electron shells are being added down the group. This trend is consistent with the expected reactivity based on ionic radii. As you move down Group 2, the atomic radius of the elements increases.Trends in Group 2 Elements Atomic Radius Trend Down Group 2 Elements in group 2 will lose two electrons to gain a full outer shell of electrons, to form ions with a +2 charge when they react. The outer shell of group 2 elements contains two electrons and is therefore represented by the sub shell s2. All the alkaline earth metals are highly reactive elements since they have a strong tendency to lose the two valences s-electrons to form the corresponding. So, it becomes comparatively easier to extract such least reactive metals. For example, Gold, Platinum is found in free state. Some of these metals are found in the earth’s crust in their free state. Group 2 elements are collectively known as the Alkaline Earth Metals. Reactivity Series - Reactivity Series of Metals refers to the Arrangement of Metals in the Descending Order of their Reactivities. Group 2, The Alkaline Earth Metals (A-Level Chemistry) Group 2, The Alkaline Earth Metals Introduction to Group 2 Elements Group 2, The Alkaline Earth Metals We hope the above methods help you in restoring the incoming call screen on your iPhone. There might be some hardware problem, especially if the screen doesn’t wake up or stays black when you receive a call. If you have tried all the aforementioned fixes with no luck, you should reach out to Apple Support to get your iPhone diagnosed for errors. To factory reset iPhone, go to Settings > General > Reset. Check out 6 things that you must not forget while backing up your iPhone. So, if the issue persists, take a complete backup of your iPhone and factory reset it. Factory resetting your iPhone will delete all data and files from your iPhone in case they aren’t saved to iCloud or any other cloud storage service. What’s a phone if you cannot see or answer incoming calls? Since incoming calls play a basic yet one of the essential roles, you might need to take the harsh step of resetting your iPhone. Step 2: Tap on Reset followed by Reset all Settings. To reset all settings, follow these steps: Find out in detail what happens by resetting iPhone settings. Those include Wi-Fi, Bluetooth, screen settings like dark mode, sound and notification settings, and others. However, all the settings on your iPhone will be reset to their default values. That will not impact your personal data on your phone or in iCloud. In this fix, you will need to reset the settings on your iPhone. Tip: Find out what happens when you update your phone’s software. Install it if available and restart your iPhone. See if a software update is available for your iPhone. Then go to Settings > General > Software update. Start by updating all apps on your iPhone from App Store. Often, there is a bug in the software, and the latest update should get it fixed. If Full screen is already selected, pick Banner and then choose Full screen again. For that, visit Settings > Phone > Incoming Calls. So if you want incoming calls to appear in full-screen, you need to turn off the Banner display style. With iOS 14, you can enable Banner style notification where the incoming call will appear as a notification banner like any other notification when unlocked. Earlier, when you received a call, it would occupy the entire screen taking you away from the app you were using. With iOS 14, Apple introduced the much-awaited feature of the condensed call screen. Tip: Check 7 ways to fix notification sounds not working on iPhone. However, to be on the safer side, you should keep notifications enabled for the Phone app. You shall see an incoming call screen irrespective of if you turn off notifications for the Phone app. In case it is already enabled, turn it off and enable it again. Enable the toggle for Allow notifications. Step 1: Open Settings on your iPhone and go Notifications. So restart your iPhone, and hopefully, you will see the incoming call banner on your iPhone. Several times, the problem is a temporary one, and a simple reboot should fix it. If your iPhone doesn’t ring at all for incoming calls, you should check our other post of calls not ringing on your iPhone. Note: The post deals with the incoming call screen not showing up on iPhone. Let’s check the solutions to fix the incoming call screen not working on iOS. Some even have the misfortune where the iPhone screen doesn’t wake up when the phone rings. Let’s see 7 ways to fix the incoming call screen not showing up on iPhone.įor several iPhone users, only the accept and reject buttons appear without displaying any caller information. They can hear the phone ring and vibrate, but nothing appears on the screen, leaving them with no choice but to miss the call. Unfortunately, the incoming call screen doesn’t show up for many iPhone users when they get a call. The typical functionality of a phone is to show you the incoming caller’s name or number when the phone rings, along with the answer and decline buttons. He offered up a few options for the frame considering the room in which it was to be hung: the aspect, wall colour, lighting and so on. The Picture Framers located between Cambridge and Royston has been my go-to place for framing for years now, so off I went to see Kevin. The finished print took a few weeks to arrive in the post, but it was worth the wait. From memory, the total cost was about £65 incl. I think I made three attempts before accepting the generated preview. You can cancel and start again if you don’t like it. Once uploaded, it sorts them randomly, and you can’t move them around. The software also checks image quality and flags any which are not up to standard. I used a 10 x 10 layout with image size at around 25% of the original, which suited me fine. It does give you options to do fewer if you want. This seemed to be the only one that could handle 100 images. Now that the cover images were saved on the drive, I found an easy-to-use online photo collage maker. Obviously, you need all 100 images in the folder before moving onto the next step. That was the exception though it found everything else. I’ve got the limited edition yellow version in the loft, and lost an hour looking in the software catalogue for that without success, so had to go with the standard red one - oh well. The only stumbling block was Pearl Jam’s ‘10’. I kept an eye on the size (normally 1-5 MB per image) to ensure the quality was good. You can then simply save them them to your computer in a dedicated folder. This searches a huge database of album covers and finds mostly high resolution images. Getting this done involved downloading a free image tool from the web. Loved that album, darn it! Finding the album artwork online The one that still slipped through the net is Rudimental’s ‘Home’. Watching The Hunger Games proved to be a good move as seeing Lenny Kravitz in the movie reminded me of his amazing album ‘Mama Said’ - a definite ‘in’. Once I had my list whittled down, I still held off for a bit and chopped and changed. Music is so powerful! The likes of Underworld’s ‘Dubnobasswithmyheadman’, Rage Against the Machine, Fugazi’s ‘Repeater’ and Doves’ ‘Lost Souls’ are all significant to me for various reasons. The brief was to keep it personal and not to try to make it ‘The Best Albums of All Time’ it was more about what formed memories or evoked emotions - stuff like that. It was hard work deciding which album covers to include, and I spent a long time physically trawling through my collection. I wanted to share this process as it has been fun and already has drawn lots of interest. Therefore, I worked out how to get the 100 album images printed as a poster using software and a cloud printing service, before getting it professionally framed. I soon realised that scanning the original covers would not give me the required quality and consistency. Most of these are also pieces of art in in their own right, so I was sure it was going to look cool. I wanted to reproduce a selection of my old CD album covers that are stuck in the loft, and present them proudly on the wall in an effort to remind myself to listen to them from time to time. In 24 championship features, there have been 18 drivers to win it just once: Ron Jones, Johnny Saathoff, Willy Kraft, Mark Noble, Dan Daniels, Kelly Shryock, Chad Kinder, Dean Mahlstedt, Tim Donlinger, Terry Phillips, Joey Jensen, Tommy Weder Jr., Ryan Gustin, Jacob Bleess and Jim Chisholm. The Fall Jamboree itself is an even tougher title to achieve. Two-time winners include last year's winner, Jim Chisholm, plus Corey Dripps, Jason Krohn, Dereck Ramirez, Ryan Ruter, Johnny Scott, Stormy Scott and Dustin Sorensen.ĭrivers who have visited victory lane here one time include Steve Arpin, Jacob Bleess, Mark Burgtorf, Cayden Carter, Dan Chapman, Dan Daniels, Les Duellman, Tony Fraise, Jordan Grabouski, Mike Hejna, Chad Kinder, Dean Mahlstedt, Brad McEwan, Tommy Myer, Mark Noble, Jeremy Payne, Mike Sorensen, Mike Spaulding, Jon Tesch, Craig Thatcher, Jake Timm, Randy Timms, Darin Walker, Tommy Weder Jr., Steve Wetzstein. Jason Cummins and Brad Waits have four apiece while Joey Jensen, Lucas Schott and Zack VanderBeek have each tallied three wins. Ryan Gustin has seven wins while Tim Donlinger, Terry Phillips and Brandon Davis-the track’s all-time winningest driver-and Jake O’Neil, who has won two of the last three Fall Jamboree finales, each have five USMTS victories. Both take a back seat, however, to Jason Hughes who has a series-best 14 victories. Nine-time USMTS national champ Kelly Shryock won the first-ever contest here in 2002-his first of 10 at Deer Creek-while Rodney Sanders has garnered 13 checkered flags here. The 125 shows in the books have produced 47 different winners. More than any other racetrack, the high-banked 3/8-mile clay oval located in the rolling hills of Southern Minnesota will be hosting Summit USMTS Modifieds for the 126th time on Thursday, Sept. Summit USRA Weekly Racing Series national points are up for grabs all three nights.Īn open practice for all competitors is scheuled for Wednesday from 6-9 p.m.įAST FACTS: 25th Annual Featherlite Fall Jamboree Saturday’s finale will dle out $1,500 to the winner. USRA B-Mods will be racing all three nights too, with twin features paying $500 to win each on Thursday and Friday. This year’s event will feature a $3,000 top prize for the Summit USMTS Modifieds on Thursday, followed by a $5,000-to-win feature on Friday and $12,000 to Saturday’s winner of the 30-car main event that will start three-wide.Ī Fall Jamboree tradition, Saturday’s annual Non-Qualifiers Race will pay $2,000 to win and $250 to start for the next 30 racers that fail to make the 30-car main event. 21-23, when the Summit USMTS National Championship presented by RacinDirt invades the Deer Creek Speedway in Spring Valley, Minn. The best of the best are preparing for the 25th Annual Featherlite Fall Jamboree on Thursday, Friday and Saturday, Sept. The Overkill Perk will allow you to brace the Automaton with an SMG like the RA 225, and the buffed Battle Hardened should be a top choice once the devs fix the ongoing issue with the Perk. This is the best combination of Perks for the Automaton in Call of Duty Warzoneįor your first Perk, you should equip E.O.D as it’ll make you more resistant to explosive damage from grenades and other throwables that adversaries might use to take you out. Best Automaton Loadout Warzone – Best Perks & Equipment If you think or consider that we should include any other particular attachment, leave us a comment below and we will be happy to analyze it on our website. If you are interested, here are some other interesting and powerful accessories for the Warzone automaton weapon. Undoubtedly, at present this is the best combination to get the most out of the weapon. The following is the best combination of attachments for the automaton in call of duty warzone. Best Automaton Loadout Warzone – Best Attachments & Build While we recommend reaching that position in Vanguard multiplayer as it’s briskly, it can effortlessly be done in Warzone. To unleash the Automaton in Warzone, players important reach position 8, so it won’t take too long. The Automaton Assault Rifle is an extremely viable pick in Warzone, and here are all the attachments and Perks needed to craft the best loadout for it in Warzone Pacific Season 5. Best Automaton Loadout Warzone – Best Attachments and alternative attachments, best Perks and best equipment – Call of Duty Warzone Fixed FFmpeg plugin crashes when stressed.Seek to cells' onset when snapping the cell.Fixed incorrect time when inserting cells on subsequently locked regions.Load the correct plugin from the OPF file.Fixed unselected spreadsheet cells when clicking on the Video Controller window.Fixed installation issues on older Mac OS versions.Re-arrange column from the Code Editor dialog.Added new Ruby API function to load a video from a script.Keep aspect ratio when resizing FFmpeg plugin window.Added support for playback speeds from 0x to 32x for Images and Audio.Stepping frame by frame forward and backward.Playback speed from -32x to +32x for Images and Audio.Shortcuts not working on Mac FFMPEG Window.ĭatavyu 1.4.2 Release Notes New Features.Controller track video resize buttons do not work.(ruby api) fix sanitization of code names when they start with a number.(ruby api) compute_kappa won't crash on edge case.(playback) fix jogging outside of locked region.(general) fix startup crash when no network connection is available.(general) fix memory leaks when removing videos.(general) fix crashing when VLC is installed.(ruby api) add function to save and load track information to/from a spreadsheet column.New installations will prompt users to share usage data.Re-work highlight and highlight and focus for more intuitive use.Videos will automatically re-open using FFMPEG. Users will receive a deprecation notice when opening Datavyu files which.Add FFMPEG as default plugin for Mac and Windows.Datavyu 1.5.0 Release Notes Notable Changes Known Issues * Shortcuts not working on Mac FFMPEG Window. (General) Select correct cell's code when highlight and focus is enabled.(General) Show mouse cursor on FFmpeg plugin video window.(General) Removed ghost window opening up with mac FFmpeg player.(General) Fixed OPFs backward compatibility with previous Native OSX plugins.(General) Fixed Datavyu Mac menubar highlight on mouse hover.(General) Fixed Datavyu crashes when no Internet connection.(Playback) Fixed FFmpeg player seeks to end of the video.(Playback) Fixed crashes when destroying FFmpeg player.(Playback) Fixed Native OSX jogging when track offset is positive.(Playback) Fixed Native OSX player speed transitions.(Playback) Fixed resizing video via the controller.(Ruby API) Improved ability to add and remove videos.(Playback) Improved FFmpeg player seeks accuracy.(Playback) Faster FFmpeg player frames rendering.(Playback) Disabled "Frame Rate" field and Added FPS label for each track.(Playback) Replaced "Steps per Second" by "Frame Rate".(Playback) Replaced steps per second by a new Shortcut to jump forward by time ( SHIFT - ).Experts are on hand to help.Datavyu 1.5.1-RC3 Development Release Notes Notable Changes (This takes a while.)Īfter your system is restored to the earlier configuration, check to see whether Windows Media Player runs correctly again.įor general help with Windows Media Player, see the Windows Media Player support page. You can also post questions about Windows Media Player errors in the Windows forum. Select Create a restore point, and then in the System Properties pane, select System Restore.įollow the prompts to select the restore point just before the round of updates that seemed to trigger the problem. To do this:Ĭlick the Start button and type system restore. If Windows Media Player stopped working correctly after the latest update from Windows Update, you can verify that the update is the problem by using System Restore. If you can't burn a CD or DVD, does the disc already have content on it? If so, make sure the disc is rewritable and that you erase the existing content before you try to burn new content onto it. For more information about codecs, see Codecs: frequently asked questions. If the error involves a playback problem, you may not have the right codec on your PC to play that file. You may get an error message while using Windows Media Player but without any specific info about the error. We recommend you move to a Windows 11 PC to continue to receive security updates from Microsoft. Support for Windows 7 ended on January 14, 2020 1-48 of over 3,000 results for "digital alarm clock" Results Price and other details may vary based on product size and color. FREE delivery Tue, Sep 12 on $25 of items shipped by Amazon. This retro clock features a Coca-Cola Delicious and Refreshing design and the high gloss chrome molded case adds a brilliant shine to the clock.Digital Alarm Clock, with 5.5" Big LED Time Display, Adjustable Alarm Volume, 6 Level Brightness, Alarm Settings, Day of The Week, USB Charger, Temperature Detect, Snooze, Clocks for Bedroom, Black. Bring the unique style of the world's most recognizable brand home with this incredible Coca-Cola clock. Toy Time Hastings Home Clocks Analog Round. Amazon Echo Show 5 (2nd Gen) Seeing how Amazon started the whole smart clock trend, it should come as no surprise that the Amazon Echo Show 5 (2nd Gen) Is one of. While there are many alarm clocks with built-in wireless phone charging capabilities, not too many offer that feature. Do alarm clocks provide wireless charging for phones? While there are many alarms with a USB input, there are many that don’t provide a USB. However, not all alarm clocks provide battery backup. In case the power goes out, an alarm clock with battery backup will still wake you up on time. Not all, but some alarm clocks have an integrated thermometer. With a few exceptions, most alarm clocks are in the ballpark between $12-$45. We highly recommend it! How much does an alarm clock cost? It’ also has outstanding customer reviews, reliable controls, many useful features, and excellent build quality. It has an eye-catching modern design that enhances your bedroom. However, our winner is the American Lifetime for a wide array of reasons. Like mentioned earlier, everyone has different needs, requirements, and budgets for their preferred alarm clock with a battery backup. Keep in mind that our opinion is not the end all be all. A good choice for fumble seniors like me who don’t want fancy extras.” Tech Specs & Details The alarm is loud enough but not jarring. The battery backup that retains settings will be helpful. Users Say: “This is a replacement for a similar clock that stopped working after about 15 years. You’ll also appreciate the built-in nightlight. Every button is on the front bottom side. The alarm itself is 7.6 x 4 x 3.7 with a pleasant digit display. It has a pretty loud beeping alarm with a useful 9-minute snooze button. Last but not least, the Sharp LED is a simplistic but solid alarm clock with battery backup. I haven’t tried the power charger on the front of the clock yet, but my phone cable fits in the slot fine.” Tech Specs & Details My hose has lost power for a few seconds, but with the battery backup, I don’t have to reset the time. I also like the different alarm sounds you can use to wake-up too. Users Say: “I really like the dual alarm setup that lets you set up the alarm for Monday through Friday, so it wakes you up automatically. With 6 adjustable sounds, snooze, FM radio, and superb customer reviews It’s a very reliable choice! You can get it in either standard black or a contemporary wooden grain. It’s dimmable between 0-100%, shows the indoor temperature of your room, and provides dual USB chargers to charge your phone or device. But besides that, there are many reasons why it’s a great choice. First up, the USCCE is an excellent alarm clock with a battery back up. Studies have shown that both the innate and adaptive immune system are important in the immune response to neoplasms. Adaptive immunity is characterized by a highly specific response to an antigen or antigens expressed by an infectious agent or a cancer cell. The innate immune response also primes the adaptive immune response. Innate immunity is defined by a broad, non-specific, inflammatory process mediated by innate immune cells such as monocytes, natural killer cells and macrophages, and soluble mediators such as lipids and cytokines. While these definitions were based largely on the host response to infection, they can be applied to the role of the immune system in cancer. The immune system is characterized by the innate immune system and the adaptive immune system. This study reinforced the observation that locoregional therapy augments systemic therapy. Recently it was shown that hyperthermic intraperitoneal chemotherapy (HIPEC) given at the time of surgery resulted in longer recurrence free survival and overall survival when compared to surgery alone. This study showed that IP delivery of agents was a viable therapeutic option, and that IP therapy could increase efficacy of treatment. The IP regimen resulted in a 15-month increase in overall survival compared to the standard IV therapy. Patients with stage III optimally resected cancer were given cisplatin intraperitoneal (IP) and paclitaxel intravenous (IV) and IP, compared to standard IV administration of both drugs. In 2006 there was a major advance in the treatment of some women diagnosed with EOC. The presence of the bulk of disease in the peritoneal cavity, and the semi-permeable nature of the peritoneum, makes ovarian cancer an ideal candidate for the use of locoregional therapy. In most women, mortality is associated with abdominal disease. Distant metastases (lung, brain) are infrequently found, and typically occur late in the course of disease. ĭespite the aggressive nature of ovarian cancer, and its high mortality rate, the disease is largely retained to the peritoneal cavity, with metastatic seeding to all of the major organs of the peritoneal cavity. Without curative second line treatment for patients with resistant or refractory epithelial ovarian cancer (EOC), median survival is 16 months, with most of the population dying within the first 2 years. The disease course is characterized by a high rate of relapse despite an initial good response to the therapy. Standard of care for the treatment of ovarian cancer is tumor cytoreductive surgery followed by administration of platinum and taxane based chemotherapy. Ovarian cancer is the leading cause of death due to gynecological malignancies, and the fifth leading cause of death due to cancer in women. Trial Registration Identifier: NCT02948426, registered on October 28, 2016. This therapy is highly unique in that it is the first study of its type using only components of the innate immune system for the locoregional delivery consisting of autologous monocytes and dual interferons alpha and gamma. We have combined the use of autologous monocytes and interferons alpha and gamma for local–regional administration directly into the peritoneal cavity. We have developed a novel immunotherapy focused on the innate immune system for the treatment of ovarian cancer. Secondary outcome measurements of changes in the peripheral blood immune compartment and plasma cytokines will be studied for correlations of response. We have designed a standard 3 + 3 dose escalation study to explore the highest tolerated dose of interferons and monocytes infused IP in patients with chemotherapy resistant ovarian cancer. Patient monocytes are isolated through counterflow elutriation and stimulated ex vivo with interferons and infused IP through a semi-permanent catheter. Due to the highly immune suppressive properties of ovarian cancer, ex vivo stimulation of autologous patient monocytes with interferons and infusion of all three agents intraperitoneally (IP) can provide a strong pro-inflammatory environment at the site of disease to kill malignant cells. Interferons have both cytostatic and cytotoxic properties, while monocytes stimulated with interferons have potent cytotoxic properties. Locoregional immune therapy using both interferons and monocytes can be used as a novel approach. Ovarian cancer has no definitive second line therapeutic options, and largely recurs in the peritoneal cavity. |
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